Table 2 Genotype frequencies and genotype-specific risks in 2192 women with breast cancer and 2257 controls
SNP | Series | Rare-allele frequency | Common homozygote No. (%) | Heterozygote No. (%) | Rare homozygote No. (%) | Number genotyped | P (2df) |
|---|---|---|---|---|---|---|---|
SNP 1 | Cases | 0.13 | 1618 (77) | 447 (21) | 42 (2) | 2107 | |
Controls | 0.13 | 1645 (75) | 511 (23) | 33 (2) | 2189 | 0.13 | |
OR (95% CI) | 1 (ref) | 0.89 (0.77–1.03) | 1.29 (0.82–2.05) | ||||
SNP 2 | Cases | 0.25 | 1151 (57) | 734 (36) | 140 (7) | 2025 | |
Controls | 0.26 | 1219 (55) | 839 (38) | 147 (7) | 2205 | 0.48 | |
OR (95% CI) | 1 (ref) | 0.93 (0.82–1.05) | 1.01 (0.79–1.29) | ||||
SNP 3 | Cases | 0.32 | 962 (47) | 855 (42) | 219 (11) | 2036 | |
Controls | 0.32 | 1022 (46) | 956 (43) | 230 (11) | 2208 | 0.69 | |
OR (95% CI) | 1 (ref) | 0.95 (0.84–1.08) | 1.01 (0.82–1.24) | ||||
SNP 4 | Cases | 0.25 | 1128 (57) | 748 (37) | 113 (6) | 1989 | |
Controls | 0.25 | 1230 (57) | 791 (37) | 134 (6) | 2155 | 0.69 | |
OR (95% CI) | 1 (ref) | 1.03 (0.91–1.17) | 0.92 (0.71–1.20) | ||||
SNP 5 | Cases | 0.33 | 911 (45) | 870 (43) | 233 (12) | 2014 | |
Controls | 0.33 | 960 (44) | 983 (45) | 238 (11) | 2181 | 0.45 | |
OR (95% CI) | 1 (ref) | 0.93 (0.82–1.06) | 1.03 (0.84–1.26) |