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Table 3 Correlation between focal adhesion kinase, HER2, estrogen receptor, phospho-Src Tyr-215 and phospho-Src Tyr-416, phospho-Akt and phospho-ERK1/2 immunohistochemistry

From: High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome

 

Focal adhesion kinase expression

P value*

 

Negative

Intermediate

Strong

 

Her-2/neu status (n = 159)

   

0.001

   Negative (0, 1+)

13

88

14

 

   Positive (2+, 3+)

0

29

15

 

Estrogen receptor status (n = 152)

   

Not significant

   Negative

4

48

10

 

   Positive

6

67

17

 

Phospho-Src Tyr-215 (n = 137)

   

0.021

   Negative

9

87

17

 

   Positive

 

15

9

 

Phospho-Src Tyr-416 (n = 140)

   

Not significant

   Negative

8

86

21

 

   Positive

 

20

5

 

Phospho-Akta (n = 162)

   

< 0.001

   Negative

7

10

1

 

   Positive

6

109

29

 

Phospho-ERK1/2 (n = 161)

   

Not significant

   Negative

5

28

9

 

   Intermediate

8

74

13

 

   Strong

 

16

8

 
  1. * P value of chi-squared analysis.
  2. aNegative, percentage of phospho-Akt-positive cells ≤ 45%; positive, percentage of phospho-Akt-positive cells > 45%.