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Table 1 Characteristics of mastectomy-treated breast cancer patients in the Surveillance, Epidemiology, and End Results (SEER) Breast Implant Surveillance Study, 1983–1989

From: Breast implants following mastectomy in women with early-stage breast cancer: prevalence and impact on survival

Characteristic All eligible patients (n = 5862) Study responders only (n = 4968)
  Nonresponders (n = 894) Responders (n = 4968) P value Women with breast implants (n = 1018) Women without breast implants (n = 3950) P value
  n % n %   n % n %  
SEER region           
   San Francisco–Oakland 468 52.4 1853 37.3 0.0001 416 40.9 1437 36.4 0.0001
   Seattle–Puget Sound 190 21.3 1663 33.5   374 36.7 1078 27.3  
   Iowa 236 26.4 1452 29.2   228 22.4 1435 36.3  
Year of diagnosis           
   1983 246 27.5 1102 22.2 0.0001 176 17.3 926 23.4 0.0003
   1985 241 27.0 1152 23.2   244 24.0 908 23.0  
   1987 230 25.7 1405 28.3   319 31.3 1086 27.5  
   1989 177 19.8 1309 26.3   279 27.4 1030 26.1  
Age at diagnosis           
   < 35 years 59 6.6 175 3.5 0.0001 88 8.6 87 2.2 0.0001
   35–44 years 231 25.8 919 18.4   334 32.8 585 14.8  
   45–54 years 256 28.6 1545 31.1   370 36.4 1175 29.8  
   55–64 years 348 38.9 2329 46.9   226 22.2 2103 53.2  
Mean age at diagnosis (years) 49.9 - 52.1 - 0.0001 46.7 - 53.4 - 0.0001
Race/ethnicity           
   Non-Hispanic White 670 74.9 4444 89.5 0.0001 959 94.2 3485 88.2 0.0001
   Non-Hispanic Black 78 8.7 150 3.0   13 1.3 137 3.5  
   Hispanic 38 4.3 131 2.6   20 2.0 111 2.8  
   Asian/Pacific Islander 86 9.6 179 3.6   16 1.6 163 4.1  
   Other/unknown 22 2.5 64 1.3   10 1.0 54 1.4  
Stage at diagnosis           
   In situ 78 8.7 567 11.4 0.04 199 19.6 368 9.3 0.0001
   Localized 562 62.9 3141 63.2   601 59.0 2540 64.3  
   Regional 241 27.0 1209 24.3   211 20.7 998 25.3  
   Unstaged 13 1.5 51 1.0   7 0.7 44 1.1  
Histology           
   Infiltrating ductal 687 76.9 3638 73.2 0.04 695 68.3 2943 74.5 0.0001
   Lobular 44 4.9 364 7.3   106 10.4 258 6.5  
   Infiltrating ductal and lobular 35 3.9 195 3.9   54 5.3 141 3.6  
   Not otherwise specified/other 128 14.3 771 15.5   163 16.0 608 15.4  
Grade           
   Well differentiated 17 1.9 150 3.0 0.02 29 2.9 121 3.1 0.91
   Moderately differentiated 128 14.3 712 14.3   137 13.5 575 14.6  
   Poorly differentiated 144 16.1 824 6.6   169 16.6 655 16.6  
   Undifferentiated 17 1.9 185 3.7   39 3.8 146 3.7  
   Unknown grade 588 65.8 3097 62.3   644 63.3 2453 62.1  
Number of primary tumors           
   One primary only 771 86.2 4001 80.5 0.0001 867 85.2 3134 79.3 0.0001
   Two or more primaries 123 13.8 967 19.5   151 14.8 816 20.7  
Radiation therapy during first course of treatment           
   No 814 91.1 4626 93.1 0.03 969 95.2 3657 92.6 0.01
   Yes 80 9.0 333 6.7   48 4.7 285 7.2  
   Unknown 0 0 9 0.2   1 0.1 8 0.2  
Vital statusa           
   Alive 538 60.2 3696 74.4 0.0001 867 85.2 2828 71.6 0.0001
   Dead 356 39.8 1272 25.6   151 14.8 1122 28.4  
  1. aFinal date of follow-up, December 1999.