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Table 5 Haplotype 2 and risk of breast cancer by family history of breast cancer in the Nurses' Health Study

From: Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer

Family history Case (frequency)a Control (frequency)a OR (95% CI) ORb (95% CI)
None     
   Other/other 668 (51) 995 (58) 1.00 (reference) 1.00 (reference)
   Hap2/other 351 (27) 456 (27) 1.16 (0.97–1.38) 1.13 (0.95–1.35)
   Hap2/Hap2 39 (2.9) 43(2.5) 1.36 (0.86–2.15) 1.34 (0.84–2.15)
Present     
   Other/other 165 (12) 145 (8) 1.69 (1.33–2.17) 1.78 (1.38–2.29)
   Hap2/other 77 (5.8) 75 (4.4) 1.51 (1.07–2.12) 1.60 (1.13–2.27)
   Hap2/Hap2 14 (1.1) 3 (0.2) 10.06 (2.25–45.0) 10.83 (2.39–49.2)
  1. CI, confidence interval; Hap2, haplotype 2; OR, odds ratio.
  2. aSamples lacking genotype information at all four SNPs were removed from haplotype analysis.
  3. bLogistic regression controlling for age, age of menopause, post-menopausal hormone use, age at first birth, parity, and history of benign breast disease. P interaction = 0.05.