Skip to main content

Table 5 Haplotype 2 and risk of breast cancer by family history of breast cancer in the Nurses' Health Study

From: Haplotype analysis of common variants in the BRCA1 gene and risk of sporadic breast cancer

Family history

Case (frequency)a

Control (frequency)a

OR (95% CI)

ORb (95% CI)

None

    

   Other/other

668 (51)

995 (58)

1.00 (reference)

1.00 (reference)

   Hap2/other

351 (27)

456 (27)

1.16 (0.97–1.38)

1.13 (0.95–1.35)

   Hap2/Hap2

39 (2.9)

43(2.5)

1.36 (0.86–2.15)

1.34 (0.84–2.15)

Present

    

   Other/other

165 (12)

145 (8)

1.69 (1.33–2.17)

1.78 (1.38–2.29)

   Hap2/other

77 (5.8)

75 (4.4)

1.51 (1.07–2.12)

1.60 (1.13–2.27)

   Hap2/Hap2

14 (1.1)

3 (0.2)

10.06 (2.25–45.0)

10.83 (2.39–49.2)

  1. CI, confidence interval; Hap2, haplotype 2; OR, odds ratio.
  2. aSamples lacking genotype information at all four SNPs were removed from haplotype analysis.
  3. bLogistic regression controlling for age, age of menopause, post-menopausal hormone use, age at first birth, parity, and history of benign breast disease. P interaction = 0.05.