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Figure 4 | Breast Cancer Research

Figure 4

From: Membrane estrogen receptor-α levels in MCF-7 breast cancer cells predict cAMP and proliferation responses

Figure 4

Effects of ICI172,780 and 17α-estradiol on cAMP production in MCF-7 cells enriched for membrane estrogen receptor-α (mERhigh) cells. (a) ICI172,780 inhibited 17β-estradiol (E2)-induced cAMP production. Both simultaneous application of 1 μmol/l ICI172,780 and 1 pmol/l E2 (open circle) or 30 min pretreatment with ICI172,780 (open square) was tested. (b) 17α-Estradiol was applied at a 10 nmol/l concentration and the time dependent cAMP production was followed. Closed circles represent E2 induced cAMP production, redrawn for comparison from Fig. 2a.

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