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Table 5 Association between parental carrier status of the variant allele(s) and breast cancer risk in daughters

From: Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study

 

Test statistic

 

Mothers' carrier status and disease risk in daughters

Fathers' carrier status and disease risk in daughters

Variant allele(s)

Additive

Dominant

Additive

Dominant

CYP17

    

   C

1.47

1.09

1.40

1.07

P

0.07

0.14

0.08

0.14

CYP19

    

   (TTTA)≥10

1.73

1.65

0.95

0.45

P

0.04

0.05

0.17

0.33

   (TTTA)11

1.52

1.96

- 0.11

0.18

P

0.06

0.03

0.46

0.43

  1. The test statistic was calculated under the additive model. P values are based on one-tailed test statistics.