Gene (sibling sets/cases/controls) | Affected (n) | Unaffected (n) | Adjusted odds ratios for breast cancer (95% CI) | |
---|---|---|---|---|
CYP17 (165/171/188) | ||||
Dominant model | TT | 59 | 56 | 1.00 |
TC/CC | 112 | 132 | 0.86 (0.47–1.59) | |
Recessive model | TC/TT | 146 | 154 | 1.00 |
CC | 25 | 34 | 0.61 (0.27–1.41) | |
General model | TT | 59 | 56 | 1.00 |
TC | 87 | 98 | 0.86 (0.47–1.59) | |
CC | 25 | 34 | 0.55 (0.21–1.42) | |
Additive model (trend per allele) | 0.77 (0.49–1.21) | |||
CYP19 (no. of TTTA repeats) (169/175/193) | ||||
Dominant model | (TTTA)<10(TTTA)<10 | 67 | 78 | 1.00 |
(TTTA)≥10(TTTA)<10/(TTTA)≥10(TTTA)≥10 | 108 | 115 | 1.24 (0.63–2.46) | |
Recessive model | (TTTA)<10(TTTA)<10/(TTTA)≥10(TTTA)<10 | 159 | 173 | 1.00 |
(TTTA)≥10(TTTA)≥10 | 16 | 20 | 0.82 (0.30–2.24) | |
General model | (TTTA)<10(TTTA)<10 | 67 | 78 | 1.00 |
(TTTA)≥10(TTTA)<10 | 92 | 95 | 1.26 (0.64–2.51) | |
(TTTA)≥10(TTTA)≥10 | 16 | 20 | 0.98 (0.30–3.18) | |
Additive model (trend per allele) | 1.11 (0.65–1.89) | |||
Dominant model | (TTTA)other(TTTA)other | 77 | 95 | 1.00 |
(TTTA)11(TTTA)other/(TTTA)11(TTTA)11 | 98 | 98 | 1.77 (0.90–3.47) | |
Recessive model | (TTTA)other(TTTA)other/(TTTA)11(TTTA)other | 165 | 179 | 1.00 |
(TTTA)11(TTTA)11 | 10 | 14 | 0.66 (0.19–2.33) | |
General model | (TTTA)other(TTTA)other | 77 | 95 | 1.00 |
(TTTA)11(TTTA)other | 88 | 84 | 1.84 (0.93–3.63) | |
(TTTA)11(TTTA)11 | 10 | 14 | 1.04 (0.27–4.08) | |
Additive model (trend per allele) | 1.38 (0.79–2.40) |