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Table 4 Conditional logistic regression analysis of discordant sibships for the association between CYP17 and CYP19 genotypes and breast cancer

From: Variants in estrogen-biosynthesis genes CYP17 and CYP19 and breast cancer risk: a family-based genetic association study

Gene (sibling sets/cases/controls)

 

Affected (n)

Unaffected (n)

Adjusted odds ratios for breast cancer (95% CI)

CYP17 (165/171/188)

    

   Dominant model

TT

59

56

1.00

 

TC/CC

112

132

0.86 (0.47–1.59)

   Recessive model

TC/TT

146

154

1.00

 

CC

25

34

0.61 (0.27–1.41)

   General model

TT

59

56

1.00

 

TC

87

98

0.86 (0.47–1.59)

 

CC

25

34

0.55 (0.21–1.42)

   Additive model (trend per allele)

0.77 (0.49–1.21)

CYP19 (no. of TTTA repeats) (169/175/193)

   Dominant model

(TTTA)<10(TTTA)<10

67

78

1.00

 

(TTTA)≥10(TTTA)<10/(TTTA)≥10(TTTA)≥10

108

115

1.24 (0.63–2.46)

   Recessive model

(TTTA)<10(TTTA)<10/(TTTA)≥10(TTTA)<10

159

173

1.00

 

(TTTA)≥10(TTTA)≥10

16

20

0.82 (0.30–2.24)

   General model

(TTTA)<10(TTTA)<10

67

78

1.00

 

(TTTA)≥10(TTTA)<10

92

95

1.26 (0.64–2.51)

 

(TTTA)≥10(TTTA)≥10

16

20

0.98 (0.30–3.18)

   Additive model (trend per allele)

1.11 (0.65–1.89)

   Dominant model

(TTTA)other(TTTA)other

77

95

1.00

 

(TTTA)11(TTTA)other/(TTTA)11(TTTA)11

98

98

1.77 (0.90–3.47)

   Recessive model

(TTTA)other(TTTA)other/(TTTA)11(TTTA)other

165

179

1.00

 

(TTTA)11(TTTA)11

10

14

0.66 (0.19–2.33)

   General model

(TTTA)other(TTTA)other

77

95

1.00

 

(TTTA)11(TTTA)other

88

84

1.84 (0.93–3.63)

 

(TTTA)11(TTTA)11

10

14

1.04 (0.27–4.08)

   Additive model (trend per allele)

1.38 (0.79–2.40)

  1. Odds ratios were adjusted for age (in years), hormone replacement use (ever/never), oral contraceptive use (ever/never), age at menarche (in years), full term pregnancies (yes/no). Each sibling set had at least one breast cancer case and one sister control. All the subjects included in the analysis had information for all the covariate variables. CI, confidence interval.