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Table 4 Odds ratios for breast cancer and total PCBs in relation to CYP1A1 M4 genotypes in white women

From: Polychlorinated biphenyls, cytochrome P450 1A1 (CYP1A1) polymorphisms, and breast cancer risk among African American women and white women in North Carolina: a population-based case-control study

Total PCBsa

CYP1A1 M4 genotype

All participants

Premenopausal

Postmenopausal

  

Patients/controls

OR (95% CI)b

Patients/controls

OR (95% CI)b

Patients/controls

OR (95% CI)b

<0.349

Non-M4

202/159

Referent

132/103

Referent

70/56

Referent

≥0.349

Non-M4

139/163

0.7 (0.5–1.0)

46/48

0.8 (0.5–1.2)

93/115

0.7 (0.4–1.1)

<0.349

Any M4

19/19

0.8 (0.4–1.6)

17/11

1.2 (0.5–2.7)

2/8

0.2 (0.0–0.9)

≥0.349

Any M4

14/17

0.7 (0.3–1.6)

5/5

0.8 (0.2–2.9)

9/12

0.7 (0.3–1.7)

ICR (95% CI)

  

0.2 (-0.6,1.0)

 

-0.1 (-1.6,1.3)

 

0.8 (0.1,1.5)

  1. aLipid-adjusted total imputed PCBs (ng/ml).
  2. bOdds ratios adjusted for age and sampling fractions.
  3. Any M1, M1/M1 or M1/non-M1; CI, confidence interval; ICR, interaction contrast ratio; non-M1, non-M1/non-M1.