Table 2 Prenatal Factors in Carolina Breast Cancer Study (CBCS) Analytic Datasets
CBCS | Analytic subgroups | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
CBCS, full dataset | CBCS, born 1948+ | Maternal age dataset | Birthweight dataset | |||||||||||||
Cases | Controls | Cases | Controls | Cases | Controls | Cases | Controls | |||||||||
n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | n | (%) | |
Number | 861 | 790 | 366 | 316 | 280 | 237 | 196 | 167 | ||||||||
Age at selection/diagnosis (years) | ||||||||||||||||
Mean ± SD | 50.26 ± 11.93 | 51.83 ± 11.65 | 39.59 ± 5.29 | 40.65 ± 4.72 | 39.19 ± 5.43 | 40.68 ± 4.63 | 38.39 ± 5.29 | 39.95 ± 4.32 | ||||||||
Median | 48 | 49 | 41 | 42 | 40 | 42 | 39 | 41 | ||||||||
Range | 23–74 | 21–74 | 23–48 | 21–47 | 23–48 | 26–47 | 23–47 | 26–47 | ||||||||
Birthplace | ||||||||||||||||
NC born | 583 | (67.7) | 550 | (69.6) | 235 | (64.2) | 207 | (65.5) | 220 | (78.6) | 198 | (83.5) | 196 | (100.0) | 167 | (100.0) |
US born (outside NC) | 261 | (30.3) | 218 | (27.6) | 121 | (33.1) | 98 | (31.0) | 60 | (21.4) | 39 | (16.5) | 0 | (0.0) | 0 | (0.0) |
Non-US born | 17 | (2.0) | 22 | (2.8) | 10 | (2.7) | 11 | (3.5) | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) | 0 | (0.0) |
Prenatal factors | ||||||||||||||||
Birthweight | ||||||||||||||||
Lower tertile | NA | NA | NA | NA | NA | NA | 73 | (37.2) | 57 | (34.1) | ||||||
Central tertile | 70 | (35.7) | 54 | (32.3) | ||||||||||||
Upper tertile | 53 | (27.0) | 56 | (33.5) | ||||||||||||
Mean ± SD | 3210.7 ± 526.1 | 3262.5 ± 550.3 | ||||||||||||||
Maternal age (years) | ||||||||||||||||
15–18 | NA | NA | NA | NA | 31 | (11.1) | 31 | (13.1) | 21 | (10.7) | 22 | (13.3) | ||||
19–22 | 51 | (18.2) | 80 | (33.8) | 34 | (17.3) | 53 | (31.9) | ||||||||
23–27 | 87 | (31.1) | 49 | (20.7) | 60 | (30.6) | 38 | (22.9) | ||||||||
28–44 | 111 | (39.6) | 77 | (32.5) | 81 | (41.3) | 53 | (31.9) | ||||||||
Mean ± SD | 26.46 ± 6.48 | 25.18 ± 6.66 | 26.63 ± 6.46) | 25.34 ± 6.82 | ||||||||||||
Paternal age (years) | ||||||||||||||||
15–22 | NA | NA | NA | NA | 39 | (14.7) | 35 | (16.1) | 26 | (14.1) | 21 | (14.0) | ||||
23–27 | 73 | (27.5) | 69 | (31.8) | 47 | (25.4) | 50 | (33.3) | ||||||||
28–34 | 87 | (32.8) | 67 | (30.9) | 66 | (35.7) | 49 | (32.7) | ||||||||
35–56 | 66 | (24.9) | 46 | (21.2) | 46 | (24.9) | 30 | (20.0) | ||||||||
Mean ± SD | 29.97 ± 7.10 | 29.54 ± 7.46 | 30.24 ± 7.06) | 29.71 ± 7.48 | ||||||||||||
Birth order (self-report) | ||||||||||||||||
First | 297 | (34.8) | 268 | (34.1) | 117 | (32.3) | 108 | (34.3) | 88 | (31.5) | 80 | (33.9) | 56 | (28.6) | 53 | (31.9) |
Second-fourth | 406 | (47.5) | 377 | (48.0) | 194 | (53.6) | 158 | (50.2) | 149 | (53.4) | 115 | (48.7) | 107 | (54.6) | 81 | (48.8) |
Fifth or higher | 151 | (17.7) | 140 | (17.8) | 51 | (14.1) | 49 | (15.6) | 42 | (15.1) | 41 | (17.4) | 33 | (16.8) | 32 | (19.3) |
Mean ± SD | 2.86 ± 2.30 | 2.87 ± 2.32 | 2.76 ± 2.12 | 2.74 ± 2.15 | 2.83 ± 2.22 | 2.84 ± 2.25 | 2.95 ± 2.22 | 3.01 ± 2.35 | ||||||||