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Figure 8 | Breast Cancer Research

Figure 8

From: Proteotypic classification of spontaneous and transgenic mammary neoplasms

Figure 8

Epithelial to mesenchymal transition (EMT) in a mouse transgenic for Myc: EMT is associated with expression of terminal differentiation markers of mesenchymal (a,b), myoepithelial (c,e,f) and luminal (d) cells, with de novo acquisition of a myoepithelial phenotype (c,e,f, arrows) by neoplastic cells. Scale bars, 80 μm (a-d) and 160 μm (e, f). 'De novo' acquisition of the myoepithelial phenotype is defined as neoplastic cells displaying a myoepithelial phenotype in a portion of the neoplasm limited to the vicinity of the areas of EMT, whereas myoepithelial differentiation was lacking in the rest of the neoplasm (not shown).

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