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Table 2 UGT1A1, UGT2B4, UGT2B7, UBT2B15, and SULT1A1 genotypes and risk of ER- and PR- breast tumors in Caucasian and Asian female breast cancer patients, Washington state

From: UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients

Gene

ER+

n

ER-

n

ORa

ER-tumor

Combinedb

PR+

n

PR-

n

ORa

PR-tumor

Combinedb

UGT1A1

        

   (TA)6/(TA)6

53

21

1.0 (ref)

1.0 (ref)

57

17

1.0 (ref)

1.0 (ref)e

   (TA)6/(TA)7

55

16

0.6 (0.2–1.3)

 

55

16

1.1 (0.5–2.6)

 

   (TA)7/(TA)7

10

0

0.0 (0.0–0.5)*

0.5 (0.2–1.1)d

9

1

0.3 (0.02–2.6)

0.2 (0.02–2.4)

UGT2B4

        

   Asp/Asp

78

21

1.0 (ref)

1.0 (ref)

81

18

1.0 (ref)

 

   Asp/Glu

30

13

1.5 (0.6–3.6)

 

30

13

2.2 (0.9–5.4)

 

   Glu/Glu

10

3

1.3 (0.3–5.9)

1.5 (0.6–3.3)d

10

3

0.9 (0.2–4.5)

 

UGT2B7

        

   His/His

31

9

1.0 (ref)

 

33

7

1.0 (ref)

 

   His/Tyr

58

12

0.6 (0.2–1.7)

 

52

18

1.5 (0.5–4.5)

 

   Tyr/Tyr

29

16

1.8 (0.6–5.2)

 

36

9

1.4 (0.4–4.5)

 

UGT2B15

        

   Asp/Asp

20

10

1.0 (ref)

1.0 (ref)

25

5

1.0 (ref)

 

   Asp/Tyr

61

19

0.5 (0.2–1.4)

 

59

21

1.3 (0.4–4.1)

 

   Tyr/Tyr

37

8

0.4 (0.1–1.2)

0.5 (0.2–1.2)d

37

8

0.6 (0.2–2.4)

 

SULT1A1

        

   Arg/Arg

49

19

1.0 (ref)

1.0 (ref)

52

16

1.0 (ref)

1.0 (ref)

   Arg/His

50

13

0.6 (0.2–1.3)

 

50

13

0.9 (0.4–2.2)

 

   His/His

19

5

0.6 (0.2–1.9)

0.6 (0.3–1.2)d

19

5

0.8 (0.2–2.6)

0.9 (0.4–2.0)d

  1. ER, estrogen receptor; OR, odds ratio; PR, progesterone receptor. aAdjusted for age, menopausal status, age at menarche, number of pregnancies lasting at least 6 months (0, 1, 2, or 3 or more), parity/age at first birth (nulliparous, age at first birth 26 or less, age at first birth more than 26), weight change since age 18, race (Asian/Caucasian), smoking, and number of ovaries remaining. bGenotypes were also evaluated with the use of dichotomous variables ('any wild-type allele' [wild-type and heterozygous individuals] and 'any variant allele' [heterozygous and homozygous variant individuals]) when patterns suggested a dominant or recessive genotype effect. cP for trend = 0.03. dOR for combined group of heterozygous and homozygous variant individuals. eOR for combined group of wild type and heterozygous individuals.