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Table 1 Selected characteristics of the Caucasian and Asian women enrolled in the Health, Eating, Activity, and Lifestyle study and asubpopulation used for investigating associations with circulating sex hormones at the 24-month follow-up

From: UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients

Characteristic

Baseline (n = 163)

Subpopulation at 24-month follow-upa (n = 89)

 

n (%)

n (%)

Age at enrollment, years

52.4 (6.5)b

57.3 (5.7)b

   40–49

59 (36)

10 (11)

   50–59

75 (46)

43 (48)

   60–69

29 (18)

36 (40)

Race

  

   Caucasian

150 (92)

82 (92)

   Asian

13 (8)

7 (8)

Number of pregnancies

  

lasting at least 6 months

 

n/a

   0

31 (19)

 

   1

27 (17)

 

   2

59 (36)

 

   3+

45 (28)

 

Weight change since age 18 (kg)

+15.8 (14.4)b

n/a

Body fat (%)

n/a

36.8 (5.5)b

Tumor receptor status

  

   ER+ tumor

124 (76)

n/a

   PR+ tumor

128 (79)

n/a

   ER+/PR+ tumor

107 (66)

n/a

   ER+/PR tumor

17 (10)

 

   ER /PR+ tumor

21 (13)

 

   ER /PR tumor

18 (11)

 

Stage of disease

  

   0, in situ

51 (31)

n/a

   I

83 (51)

 

   II

29 (18)

 

Subject genotypes

  

   UGT1A1 genotypes (TA)6/(TA)7

  

   (TA)6/(TA)6

80 (49)

49 (55)

   (TA)6/(TA)7

72 (44)

36 (40)

   (TA)7/(TA)7

11 (7)

4 (5)

   (TA)7 allele frequency

0.29

0.25

UGT2B4 genotypes (Asp458Glu)

  

   Asp/Asp

104 (64)

53 (60)

   Asp/Glu

46 (28)

29 (33)

   Glu/Glu

13 (8)

7 (8)

   Glu allele frequency

0.22

0.24

UGT2B7 genotypes (His268Tyr)

  

   His/His

41 (25)

24 (27)

   His/Tyr

73 (45)

48 (54)

   Tyr/Tyr

49 (30)

17 (19)

   Tyr allele frequency

0.52

0.46

UGT2B15 genotypes (Asp85Tyr)

  

   Asp/Asp

32 (20)

19 (21)

   Asp/Tyr

83 (51)

47 (53)

   Tyr/Tyr

48 (29)

23 (26)

   Tyr allele frequency

0.55

0.52

SULT1A1 genotypes (Arg213His)

  

   Arg/Arg

71 (43)

39 (44)

   Arg/His

68 (42)

38 (43)

   His/His

24 (15)

12 (13)

   His allele frequency

0.36

0.35

  1. ER, estrogen receptor; n/a, not applicable; PR, progesterone receptor. aRestricted to postmenopausal women not taking estrogen or progesterone therapy at the time of blood draw for investigation of associations between genotype and sex hormone concentrations. bMean (SD).