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Table 7 Odds ratios (ORs) for breast cancer and smoking in relation to the CYP1A1 genotype at the M4 locus (white women only)

From: Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

 

M4 genotypesa

wt genotypeb

 

Cases/controls

OR (95% CI)c

Cases/controls

OR (95% CI)c

Active smoking status

    

   Never

24/16

Reference

177/190

Reference

   Former

13/8

1.2 (0.4–3.6)

123/116

1.1 (0.8–1.6)

   Current

2/16

0.1 (0.0–0.4)

78/71

1.2 (0.8–1.7)

Number of cigarettes (pack/day)

    

   Never

24/16

Reference

177/190

Reference

   ≤ 1

8/14

0.4 (0.1–1.2)

128/111

1.2 (0.9–1.7)

   > 1

7/10

0.5 (0.2–1.6)

71/75

1.0 (0.7–1.5)

Duration of smoking

    

   Never

24/16

Reference

177/190

Reference

   ≤ 20 years

11/12

0.6 (0.2–1.8)

100/104

0.9 (0.6–1.3)

   > 20 years

4/12

0.2 (0.1–0.9)

101/83

1.5 (1.0–2.1)

Former smokers: time since cessation of smoking

    

   Never

24/16

Reference

177/190

Reference

   < 10 years

6/3

1.4 (0.3–6.6)

67/48

1.4 (0.9–2.2)

   ≥ 10 years

7/5

1.0 (0.3–3.8)

56/68

0.9 (0.6–1.4)

Age started smoking

    

   Never

24/16

Reference

177/190

Reference

   < 18 years

7/9

0.5 (0.2–1.8)

71/66

1.1 (0.7–1.6)

   ≥ 18 years

8/15

0.4 (0.1–1.1)

130/121

1.2 (0.9–1.7)

  1. CI, confidence interval; wt, wild type. a M4/M4 and M4/wt genotypes. b wt/wt genotype. cAdjusted for age, race, and sampling fractions.