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Table 6 Odds ratios (ORs) for breast cancer and smoking in relation to the CYP1A1 genotype at the M3 locus (African-American women only)

From: Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

 

M3 genotypesa

wt genotypeb

 

Cases/controls

OR (95% CI)c

Cases/controls

OR (95% CI)c

Active smoking status

    

   Never

24/32

Referent

124/134

Reference

   Former

16/11

1.9 (0.7–4.8)

58/42

1.7 (1.1–2.7)

   Current

7/10

0.9 (0.7–2.8)

36/51

0.8 (0.5–1.3)

Number of cigarettes (pack/day)

    

   Never

24/32

Referent

124/134

Reference

   ≤ 1

18/16

1.5 (0.6–3.5)

79/82

1.2 (0.8–1.7)

   > 1

5/5

1.2 (0.3–4.7)

14/11

1.6 (0.7–3.8)

Duration of smoking

    

   Never

24/32

Referent

124/134

Reference

   ≤ 20 years

8/13

0.8 (0.3–2.2)

54/55

1.2 (0.7–1.8)

   > 20 years

15/8

2.5 (0.9–7.1)

39/37

1.3 (0.8–2.2)

Former smokers: time since cessation of smoking

    

   Never

24/32

Referent

124/134

Reference

   < 10 years

13/4

4.2 (1.2–14.6)

32/13

3.1 (1.5–6.1)

   ≥ 10 years

3/7

0.5 (0.1–2.3)

26/29

1.1 (0.6–2.0)

Age started smoking

    

   Never

24/32

Referent

124/134

Reference

   < 18 years

12/6

2.4 (0.8–7.5)

33/29

1.3 (0.7–2.3)

   ≥ 18 years

11/15

1.0 (0.4–2.5)

61/64

1.2 (0.8–1.8)

  1. CI, confidence interval; wt, wild type. a M3/M3 and M3/wt genotypes. b wt/wt genotype. cAdjusted for age and sampling fractions.