Skip to main content

Table 4 Odds ratios (ORs) for breast cancer and smoking in relation to the CYP1A1 genotype at the M1 locus, according to menopausal status (White and African-American women combined)

From: Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

 

All participants

Premenopausal

Postmenopausal

 

M1 genotypea

wt genotypeb

M1 genotype

wt genotype

M1 genotype

wt genotype

 

Cases/controls

OR (95% CI)c

Cases/controls

OR (95% CI)c

Cases/controls

OR (95% CI)c

Cases/controls

OR (95% CI)c

Cases/controls

OR (95% CI)c

Cases/controls

OR (95% CI)c

Active smoking status

            

   Never

96/115

Reference

252/256

Reference

46/47

Reference

132/120

Reference

50/68

Reference

120/136

Reference

   Former

65/47

1.7 (1.1–2.8)

143/129

1.2 (0.9–1.6)

37/26

1.5 (0.8–2.9)

62/53

1.0 (0.7–1.6)

28/21

1.9 (1.0–3.8)

81/76

1.3 (0.9–1.9)

   Current

35/43

1.1 (0.6–1.8)

87/105

0.8 (0.6–1.2)

20/25

0.8 (0.4–1.7)

48/48

0.9 (0.6–1.4)

15/18

1.2 (0.6–2.7)

39/57

0.8 (0.5–1.3)

Number of cigarettes smoked (pack/day)

            

   Never

96/115

Reference

252/256

Reference

46/47

Reference

132/120

Reference

50/58

Reference

120/136

Reference

   ≤ 1

71/64

1.4 (0.9–2.2)

159/159

1.0 (0.8–1.4)

43/38

1.2 (0.6–2.2)

76/70

1.0 (0.6–1.5)

28/26

1.6 (0.8–3.0)

83/89

1.1 (0.7–1.6)

   >1

29/26

1.4 (0.8–2.7)

68/74

1.0 (0.7–1.4)

14/13

1.1 (0.5–2.7)

32/30

0.9 (0.5–1.7)

15/13

1.7 (0.7–4.0)

36/44

1.0 (0.6–1.6)

Duration of smoking

            

   Never

96/115

Reference

252/256

Reference

46/47

Reference

132/120

Reference

50/58

Reference

120/136

Reference

   ≤ 20 years

51/57

1.0 (0.6–1.7)

119/127

0.9 (0.7–1.3)

37/39

1.0 (0.5–1.8)

80/77

0.9 (0.6–1.4)

14/18

1.1 (0.5–2.4)

39/50

0.9 (0.6–1.5)

   > 20 years

49/33

2.1 (1.2–3.5)

110/106

1.2 (0.9–1.6)

20/12

1.9 (0.8–4.4)

30/23

1.2 (0.7–2.2)

29/21

2.1 (1.0–4.1)

80/83

1.2 (0.8–1.7)

Former smokers: time since cessation of smoking

            

   Never

96/115

Reference

252/256

Reference

46/47

Reference

132/120

Reference

50/58

Reference

120/136

Reference

   < 10 years

41/14

3.7 (1.9–7.3)

76/53

1.5 (1.0–2.2)

23/8

2.9 (1.2–7.3)

33/24

1.1 (0.6–2.1)

18/6

4.6 (1.7–12.5)

43/29

1.8 (1.0–3.0)

   ≥ 10 years

24/33

1.0 (0.5–1.7)

67/76

1.0 (0.7–1.4)

14/18

0.8 (0.4–2.0)

29/29

0.9 (0.5–1.7)

10/15

0.9 (0.4–2.3)

38/47

1.0 (0.6–1.6)

Age started of smoking

            

   Never

96/115

Reference

252/256

Reference

46/47

Reference

132/120

Reference

50/58

Reference

120/136

Reference

   <18 years

35/25

1.7 (0.9–3.0)

87/84

1.0 (0.7–1.5)

24/12

1.9 (0.8–4.3)

45/44

0.9 (0.5–1.4)

11/13

1.2 (0.5–3.0)

42/40

1.2 (0.8–2.1)

   ≥ 18 years

65/65

1.3 (0.9–2.1)

143/150

1.0 (0.8–1.4)

33/39

0.9 (0.5–1.7)

65/57

1.1 (0.7–1.7)

32/26

1.8 (0.9–3.4)

78/93

1.0 (0.7–1.5)

Exposure to ETS

            

   Unexposed to active smoking or ETS after age 18

36/48

Reference

95/84

Reference

20/29

Reference

56/51

Reference

16/19

Reference

39/33

Reference

   ETS after age 18

60/67

1.4 (0.8–2.5)

156/172

0.9 (0.7–1.4)

26/18

2.5 (1.0–6.1)

76/69

1.2 (0.7–2.0)

34/49

0.7 (0.3–1.7)

80/103

0.7 (0.4–1.2)

  1. CI, confidence interval; wt, wild type; ETS, environmental tobacco smoke. a M1/M1 and M1/wt genotypes. b wt/wt genotype. cAdjusted for age, race, and sampling fractions.