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Table 2 Odds ratios (ORs) for breast cancer in relation to the CYP1A1 genotypes, in African-American and white women

From: Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women

 

Overall

African Americans

Whites

 

Cases

Controls

OR (95% CI)a

Cases

Controls

OR (95% CI)b

Cases

Controls

OR (95% CI)b

M1 locus

         

   wt/wt

482

490

Reference

155

165

Reference

327

325

Reference

   M1/wt

171

185

1.0 (0.7–1.2)

93

102

1.0 (0.7–1.4)

78

83

0.9 (0.7–1.3)

   M1/M1

25

20

1.2 (0.7–2.3)

17

13

1.3 (0.6–2.8)

8

7

1.1 (0.4–3.2)

   M1/wt or M1/M1

196

205

1.0 (0.8–1.2)

110

115

1.0 (0.7–1.4)

86

90

1.0 (0.7–1.3)

   Missing

10

7

6

5

4

2

   

M2 locus

         

   wt/wt

644

652

Reference

259

274

Reference

385

378

Reference

   M2/wt

41

48

0.8 (0.5–1.3)

12

11

1.0 (0.4–2.4)

29

37

0.8 (0.5–1.3)

   M2/M2

3

2

1.3 (0.2–7.7)c

0

0

nd

3

2

1.3 (0.2–8.2)c

   M2/wt or M2/M2

44

50

0.9 (0.6–1.3)

12

11

1.0 (0.4–2.4)

32

39

0.8 (0.5–1.3)

   Missing

0

0

0

0

0

0

   

M3 locus

         

   wt/wt

630

640

Reference

218

227

Reference

412

413

Reference

   M3/wt

48

48

1.1 (0.7–1.7)

47

47

1.1 (0.7–1.7)

1

1

0.7 (0.0–11.4)c

   M3/M3

0

7

nd

0

6

nd

0

1

nd

   M3/wt or M3/M3

48

55

0.9 (0.6–1.4)

47

53

1.0 (0.6–1.5)

1

2

0.4 (0.0–4.0)c

   Missing

10

7

6

5

4

2

   

M4 locus

         

   wt/wt

645

655

Reference

267

278

Reference

378

377

Reference

   M4/wt

41

47

0.9 (0.6–1.4)

3

7

0.5 (0.1–1.8)c

38

40

1.0 (0.6–1.6)

   M4/M4

2

0

nd

1

0

nd

1

0

nd

   M4/wt or M4/M4

43

47

0.9 (0.6–1.4)

4

7

0.6 (0.2–2.0)c

39

40

1.0 (0.6–1.6)

   Missing

0

0

0

0

0

0

   
  1. CI, confidence interval; wt, wild type; nd, not determined. a Adjusted for age, race, and sampling fractions. b Adjusted for age and sampling fractions. c Imprecise estimate.