Table 3 Association of HIF-1α with cell cycle-related proteins in estrogen receptor-positive (n = 52) and estrogen receptor-negative (n = 98) breast cancers
Protein | Cutoff value | ER-positive | ER-negative | ||||
|---|---|---|---|---|---|---|---|
HIF-1 α | P(χ2) | HIF-1 α | P(χ2) | ||||
<5% | ≥5% | <5% | ≥5% | ||||
Ki-67 | ≤10% | 24 | 7 | 0.624 | 34 | 6 | <0.001 |
>10% | 15 | 7 | 26 | 32 | |||
Cyclin A | ≤10% | 28 | 9 | 0.756 | 39 | 10 | <0.001 |
>10% | 10 | 4 | 21 | 28 | |||
Cyclin D1 | ≤10% | 25 | 9 | 0.736 | 55 | 35 | 0.938 |
>10% | 14 | 4 | 5 | 3 | |||
p21 | ≤10% | 33 | 7 | 0.023 | 56 | 34 | 0.497 |
>10% | 6 | 6 | 4 | 4 | |||
p53 | ≤25% | 36 | 11 | 0.415 | 53 | 24 | 0.003 |
>25% | 3 | 2 | 7 | 14 | |||
Bcl-2 | Negative | 0 | 0 | 0.609 | 4 | 5 | 0.048 |
Moderate | 12 | 5 | 23 | 21 | |||
Strong | 27 | 8 | 33 | 11 | |||
VEGF | Weak | 8 | 2 | 0.685 | 21 | 4 | 0.007 |
Strong | 31 | 11 | 39 | 34 | |||
HER-2/neu | Negative | 36 | 9 | 0.035 | 55 | 26 | 0.003 |
Positive | 3 | 4 | 5 | 12 | |||