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Table 2 Mammary carcinogenesis in N-methyl-N-nitrosourea injected rats

From: Insulin-like growth factor (IGF)-I obliterates the pregnancy-associated protection against mammary carcinogenesis in rats: evidence that IGF-I enhances cancer progression through estrogen receptor-α activation via the mitogen-activated protein kinase pathway

Groups

Cancer incidence (%)

Cancer load number/rat (mean ± SEM)

Latency range (days)

P-UN (n = 6)

16*

0.167

121

P-IGF-I (n = 6)

83

2.17 ± 0.75

57–176

AMV (n = 6)

100

2.20 ± 0.45

92–217

  1. Mammary tumor incidence, latency, and load in untreated parous rats (P-Un), parous rats treated with insulin-like growth factor -I, and in virgin rats that were age matched with the parous animals (AMV). *P < 0.05 versus P-IGF-I and AMV.
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Breast Cancer Research

ISSN: 1465-542X

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