Table 4 Studies on the ATM IVS10-6T→G variant in breast cancer
From: Frequency of the ATM IVS10-6T→G variant in Australian multiple-case breast cancer families
Reference (year) | Location | Frequency of cases with mutation | Frequency of controls with mutation | Comments |
|---|---|---|---|---|
[22] (2000) | The Netherlands | 3/82 (3.7%) | 2/268 (0.7%) | Cases aged less than 45 years |
[29] (2001) | Germany | 7/1000 (0.7%) | 3/500 (0.6%) | Unselected cases |
[32] (2002) | USA | 0/43 | 1/43 (2.3%) | Unselected cases |
[19] (2002) | Australia and New Zealand | 2/76 (2.6%) 4/144 (2.8%)a | 0/68 | Strong FHx, non-BRCA1/2, male breast cancer excluded |
[20] (2002) | Sweden and Czech Republic | 2/768 (0.3%) | 5/557 (0.2%) | Unselected cases and FHx (non-BRCA1/2) |
[30] (2003) | The Netherlands | 3/193 (1.6%) 3/233 (1.3%) | 2/268 (0.7%) | FHx, non-BRCA1/2 Cases aged less than 45 years |
[23] (2003) | USA and Denmark | 1/511 (0.2%) | 8/638 (1.3%) | Bilateral versus unilateral breast cancer (control group) unselected for FHx |
[21] (2004) | The Netherlands and Austria | 8/961 (0.8%) 1/211 (0.5%) | 4/543 (0.7%) | Non-BRCA1/2 families BRCA1/2 families |
This study | Australia | 7/495 (1.4%) | 6/725 (0.8%) [28] |