Table 1 Features of the probands and their families analyzed for EP300 germline mutations
| Â | Â | Â | Number of tumours in the family1 | |||||
|---|---|---|---|---|---|---|---|---|
Proband | Proband tumour site | Proband age at onset (years) | Breast | Ovary | Bowel | Pancreatic | Stomach | Other |
0011 | br | 32 | 8 | 0 | 1 | 0 | 2 | 0 |
0017 | br | 70 | 3 | 0 | 0 | 0 | 1 | 0 |
0187 | br/bil | 28/39 | 7 | 0 | 1 | 0 | 0 | 0 |
0318 | br/ov | 41/46 | 7 | 2 | 1 | 0 | 1 | 1 |
0329 | br | 43 | 3 | 0 | 1 | 0 | 0 | 1 |
0342 | br | 41 | 2 | 0 | 0 | 0 | 1 | 1 |
0458 | br | 46 | 4 | 0 | 0 | 0 | 1 | 3 |
0580 | br | 44 | 5 | 1 | 2 | 0 | 0 | 1 |
0894 | br | 45 | 5 | 0 | 0 | 1 | 0 | 1 |
0933 | br | 50 | 4 | 0 | 0 | 1 | 0 | 1 |
0990 | br | 42 | 4 | 0 | 1 | 0 | 0 | 2 |
1018 | br | 66 | 5 | 0 | 3 | 0 | 1 | 8 |
1115 | br | 49 | 6 | 1 | 1 | 0 | 3 | 4 |
1279 | br | 41 | 4 | 0 | 2 | 0 | 0 | 4 |
1566 | br | 53 | 4 | 0 | 1 | 0 | 1 | 4 |
1853 | br/bil | 43/47 | 2 | 0 | 2 | 0 | 0 | 1 |
1890 | br/stom | 21/49 | 2 | 0 | 6 | 0 | 0 | 5 |
1934 | br | 49 | 4 | 0 | 3 | 0 | 0 | 3 |
2033 | br/stom/th | 37/58/59 | 3 | 0 | 0 | 0 | 1 | 1 |
2220 | br | 29 | 5 | 0 | 1 | 1 | 0 | 4 |
2263 | br | 38 | 4 | 0 | 4 | 0 | 0 | 1 |
4734 | br | 49 | 6 | 0 | 2 | 0 | 0 | 7 |
0001 | br | 37 | 2 | 0 | 1 | 0 | 0 | 0 |