Table 3 Genotype frequencies of tumour necrosis factor (TNF) polymorphisms in relation to pathological indices of breast cancer severity

TNF -238 polymorphism

Nodal status

   Negative

387 (88.8)

46 (10.6)

3 (0.7)

   Positive

171 (85.5)

29 (14.5)

0 (0)

0.20^a

Grade

   Grade 1/2

363 (88.1)

47 (11.4)

2 (0.5)

   Grade 3

189 (87.1)

27 (12.4)

1 (0.5)

0.87^a

Vascular invasion

   Negative

417 (88.3)

53 (11.2)

2 (0.4)

   Positive

105 (89.0)

13 (11.0)

0 (0)

1.0^a

TNF -308 polymorphism

Nodal status

   Negative

299 (68.9)

123 (28.3)

12 (2.8)

   Positive

129 (64.8)

62 (31.2)

8 (4.0)

0.50^b

Grade

   Grade 1/2

286 (69.6)

112 (27.3)

13 (3.2)

   Grade 3

140 (65.1)

68 (31.6)

7 (3.3)

0.50^b

Vascular invasion

   Negative

326 (69.2)

132 (28.0)

13 (2.8)

   Positive

70 (60.3)

38 (32.8)

8 (6.9)

0.044^b