Table 1 Ascertainment criteria for clinic-based families, including Ashkenazi Jewish, identified at five sites from 1996 to 2000

Geographic area

Philadelphia

New York, New Jersey, Connecticut

Salt Lake City

Melbourne, Sydney

Province of Ontario

Recruitment criteria for families

Male with breast cancer; female with breast or ovarian cancer diagnosed at age <35; female with breast and ovarian cancer diagnosed at any age; female with bilateral breast cancer and first diagnosis at age <50; two individuals in two generations with breast or ovarian cancer; BRCA1 or BRCA2 mutation carrier

Male with breast cancer; female with breast or ovarian cancer diagnosed at age <45; female with breast and ovarian cancer diagnosed at any age; two first- or second-degree or three first-, second-, or third-degree relatives with breast or ovarian cancer; BRCA1 or BRCA2 mutation carrier

Male with breast cancer; female with breast or ovarian cancer diagnosed at age <45; female with breast and ovarian cancer diagnosed at any age; three individuals in two generations with breast or ovarian cancer, one diagnosed at age <45; BRCA1 or BRCA2 mutation carrier

Two or more first- or second-degree relatives with breast or ovarian cancer plus one or more of the following: additional relative(s) with breast or ovarian cancer, breast cancer diagnosed at age <40, ovarian cancer diagnosed at any age, bilateral breast cancer, both breast and ovarian cancer, breast cancer in a male relative

Recruitment criteria for Ashkenazi Jewish families

One Jewish parent

Same criteria as above

Female with breast or ovarian cancer; one or more first- or second-degree relatives with breast or ovarian cancer

One Jewish grandparent

Relationship to proband

First- and second- degree relative

First-, second-, and third-degree relative

Any relative

Any relative