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Figure 3 | Breast Cancer Research

Figure 3

From: Estrogen receptor transcription and transactivation Structure-function relationship in DNA- and ligand-binding domains of estrogen receptors

Figure 3

(a) Three-dimensional structure of the wild-type ER LBD monomer, with the β-sheet colored in blue. (b) Anchoring of the estradiol in the active site. The 3-hydroxyl group is hydrogen-bonded to Arg 394 and Glu 353 and a structural water molecule represented in green. The 17-β hydroxyl group forms a hydrogen bond with His 524. (c) Superposition of the three-dimensional structure of ERα LBD complexed with estradiol (green conformation), raloxifen and tamoxifen (red and blue conformations). (d) The ligand pocket of human ERβ showing the residues that are different in human ERα. The ERβ residue names and numbers are shown in black, the ERα residue names are in grey.

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