Table 1 Selected characteristics of study subjects by ethnicity and menopausal status
With CYP1A2 results | No CYP1A2 results5 | ||||
|---|---|---|---|---|---|
Caucasian1: pre (n = 125); post (n = 126) | East Asian2: pre (n = 4); post (n = 6) | Jewish3: pre (n = 10); post (n = 5) | Other4: pre (n = 7); post (n = 12) | Pre (n = 36); post (n = 26) | |
Premenopausal | |||||
Risk factors | |||||
Age (years) | 44.8 (4.8) | 46.8 (4.5) | 45.4 (3.1) | 44.7 (5.1) | 45.1 (4.4) |
Weight (kg) | 68.1 (16.6) | 54.8 (3.1) | 59.4 (10.7) | 64.9 (17.9) | 69.1 (13.3) |
BMI (kg/m2) | 25.3 (6.1) | 23.2 (0.9) | 22.6 (3.5) | 25.9 (6.5) | 25.8 (5.1) |
WHR | 0.75 (0.06) | 0.75 (0.04) | 0.73 (0.07) | 0.77 (0.05) | 0.74 (0.06) |
Age at menarche (years) | 12.8 (1.5) | 11.5 (1.3) | 12.2 (0.6) | 13.7 (1.6) | 12.6 (1.5) |
Age at first birth (years) | 27.8 (5.7) | 29.5 (0.7) | 29.5 (2.7) | 25.6 (9.7) | 29.0 (6.4) |
Number of live births | 1.4 (1.2) | 1.0 (1.2) | 2.1 (1.3) | 1.6 (1.3) | 1.5 (1.2) |
Mammographic density (%)6 | 27.4 (23.2) | 47.6 (17.0) | 40.2 (22.7) | 25.9 (20.0) | 28.4 (20.5) |
CYP1A2 activity7 | 6.31 (2.95) | 6.52 (0.98) | 4.98 (1.04) | 6.11 (3.50) | - |
Markers of oxidative stress | |||||
Serum MDA (μmol/l) | 1.47 (0.58) | 1.52 (0.47) | 1.53 (1.05) | 1.77 (0.68) | 1.45 (0.66) |
Urinary MDA (μmol/day) | 2855.3 (1514.1) | 3591.6 (1365.9) | 2813.0 (1392.2) | 2293.9 (1116.9) | 3729.4 (1365.9) |
dG-MDA (ρmol/mg DNA) | 200.8 (157.9) | 232.8 (115.7) | 221.4 (164.6) | 169.31 (76.27) | 180.2 (135) |
Postmenopausal | |||||
Risk factors | |||||
Age (years) | 56.3 (4.6) | 54.8 (3.8) | 53.4 (2.5) | 55.9 (4.2) | 56.0 (4.5) |
Weight (kg) | 72.5 (16.6) | 55.8 (9.8) | 70.5 (18.1) | 66.6 (15.7) | 63.7 (17.0) |
BMI (kg/m2) | 26.8 (6.2) | 23.2 (4.7) | 25.9 (6.8) | 25.6 (5.4) | 23.3 (5.2) |
WHR | 0.77 (0.07) | 0.77 (0.08) | 0.80 (0.09) | 0.80 (0.06) | 0.75 (0.11) |
Age at menarche (years) | 13.1 (1.6) | 13.0 (1.7) | 12.6 (2.6) | 13.0 (2.1) | 12.8 (1.70) |
Age at menopause (years) | 49.1 (4.8) | 50.8 (3.3) | 49.1 (3.7) | 48.8 (2.5) | 48.2 (4.3) |
Age at first birth (years) | 26.0 (5.2) | 34.6 (6.8) | 22.8 (3.8) | 31.0 (8.7) | 25.4 (4.1) |
Number of live births | 1.8 (1.5) | 1.8 (1.5) | 2.2 (1.6) | 1.0 (1.0) | 1.4 (1.4) |
Mammographic density (%)6 | 19.8 (18.5) | 48.2 (8.9) | 22.3 (24.6) | 30.1 (23.8) | 36.0 (22.1) |
CYP1A2 activity7 | 5.73 (2.18) | 8.86 (1.83) | 3.49 (1.75) | 6.64 (2.81) | - |
Markers of oxidative stress | |||||
Serum MDA (μmol/l) | 1.75 (0.65) | 1.83 (0.59) | 1.69 (0.74) | 1.64 (0.7) | 1.84 (0.72) |
Urinary MDA (μmol/day) | 3518.5 (1587.5) | 4636.2 (1348.3) | 3412.9 (978.9) | 3717.0 (1926.2) | 2449.3 (1301.8) |
dG-MDA (ρmol/mg DNA) | 197.7 (112.6) | 149.9 (107.2) | 158.2 (108.1) | 212.9 (80.8) | 203.2 (109.6) |