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Table 1 Serum hormone levels in adult wild-type and αERKO mice

From: Estrogen receptor transcription and transactivation Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action

 

Female

Male

Hormone

Wild type

αERKO

Wild type

αERKO

Gonadal steroids

    

   Estradiol (pg/ml)†

29.5 ± 2.5

84.3 ± 12.5*

11.8 ± 3.4

12.9 ± 3.4

   Progesterone (ng/ml)†

2.3 ± 0.6

4.0 ± 1.1

0.5 ± 0.3

0.3 ± 0.1

   Testosterone (ng/ml)

0.4 ± 0.4

3.2 ± 0.6

9.3 ± 4.0

16.0 ± 2.3

Anterior pituitary

    

   LH (ng/ml)

0.3 ± 0.04

1.7 ± 0.3*

2.4 ± 1.2

3.7 ± 0.7

   FSH (ng/ml)

4.9 ± 0.6

5.4 ± 0.7

26.0 ± 1.4

30.0 ± 1.1

   Prolactin (ng/ml)

18.8 ± 10.7

3.5 ± 1.3

ND

ND

  1. Data presented as mean ± standard error of the mean. ERKO, Estrogen receptor knockout; FSH, follicle stimulating hormone; LH, luteinizing hormone; ND, not determined. †These values in the female are different than those reported by Couse et al [43*], which were carried out on pooled sera. The values above are the means from assays on individual samples and therefore are more likely to reflect the true levels in the two genotypes. * t-test, wild type versus ERKO, P < 0.001. Reproduced with permission from Couse and Korach [5**].
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Breast Cancer Research

ISSN: 1465-542X

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