Skip to main content
Figure 3 | Breast Cancer Research

Figure 3

From: Estrogen receptor transcription and transactivation Estrogen receptor knockout mice: what their phenotypes reveal about mechanisms of estrogen action

Figure 3

Uterine and vaginal histology of adult ERKO mice. Histological analysis of the uterus (top panels) and vagina (bottom panels) shows the βERKO tissue is indistinguishable from the wild type, showing the normal organization of the uterine tissue into the epithelial (Ep), stromal (St) and myometrial (My) compartments. In contrast, the αERKO uterine tissue is composed of all three layers, yet they are all immature and hypoplastic. Note also the glands are fewer in number. The vagina of the wild-type and βERKO mice is identical and cornified, indicating response to estrogen, while the αERKO vagina shows no cornification. (Reproduced with permission from Couse and Korach [5**].)

Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us