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Table 5 Relationships between mRNA values of the seven selected genes and the ERα gene in the 97 estrogen receptor alpha (ERα)-positive breast tumor series

From: Relationship between intratumoral expression of genes coding for xenobiotic-metabolizing enzymes and benefit from adjuvant tamoxifen in estrogen receptor alpha-positive postmenopausal breast carcinoma

 

CYP2B6

FMO5

NAT1

SULT2B1

GSTM3

ABCC11

ESR1/ERα

CYP2A6

+ 0.471 [< 0.001]

+ 0.171 [NS (0.091)]

+ 0.248 [0.014]

+ 0.084 [NS (0.42)]

-0.037 [NS (0.72)]

-0.173 [NS (0.086)]

+ 0.281 [0.0053]

CYP2B6

 

+ 0.525 [< 0.001]

+ 0.433 [< 0.001]

+ 0.083 [NS (0.42)]

+ 0.022 [NS (0.83)]

+ 0.022 [NS (0.82)]

+ 0.409 [< 0.001]

FMO5

  

+ 0.420 [< 0.001]

-0.099 [NS (0.34)]

-0.008 [NS (0.93)]

+ 0.216 [0.032]

+ 0.316 [0.0018]

NAT1

   

+ 0.077 [NS (0.46)]

+ 0.104 [NS (0.31)]

+ 0.041 [NS (0.69)]

+ 0.293 [0.0037]

SULT2B1

    

+ 0.232 [0.021]

+ 0.049 [NS (0.64)]

+ 0.091 [NS (0.38)]

GSTM3

     

+ 0.198 [0.049]

+ 0.239 [0.018]

ABCC11

      

+ 0.023 [NS (0.82)]

  1. Data presented as Spearman rank correlation coefficient [P value (Spearman rank correlation test)]. NS, not significant.