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Table 1 Distribution of patient-related, tumor-related and therapy-related parameters and cross-tabulations with hypoxia-inducible factor 1 alpha (hif-1α) expression

From: Hypoxia-inducible factor 1 alpha in high-risk breast cancer: an independent prognostic parameter?

  

hif-1α

 

Parameter

n (%)

Negative

Weak

Strong

P

Total

77 (100)

34 (44)

25 (33)

18 (23)

 

Age

     

   <50 years

23 (30)

8 (35)

10 (43)

5 (22)

0.38

   >50 years

54 (70)

26 (48)

15 (28)

13 (24)

 

T stage

     

   T1/T2

55 (71)

26 (48)

16 (30)

13 (22)

0.57

   T3/T4

22 (29)

8 (36)

9 (41)

5 (23)

 

Differentiation/grade

     

   Moderate/G2

43 (56)

20 (46)

12 (28)

11 (26)

0.68

   Poor/G3

32 (42)

12 (37)

13 (41)

7 (22)

 

Number of lymph nodes

     

   1–3

27 (35)

14 (52)

8 (30)

5 (18)

0.58

   ≥4

50 (65)

20 (40)

17 (34)

13 (26)

 

Estrogen receptor

     

   Positive

51 (66)

26 (51)

14 (27)

11 (22)

0.23

   Negative

26 (34)

8 (31)

11 (42)

7 (27)

 

Progesterone receptor

     

   Positive

41 (53)

25 (61)

9 (22)

7 (17)

0.006

   Negative

36 (47)

9 (25)

16 (44)

11 (31)

 

Hormonotherapy

     

   Yes

62 (81)

27(43)

19(31)

16(26)

0.56

   No

15 (19)

7(47)

6(40)

2(13)

 

Chemotherapy

     

   Yes

64 (83)

25(39)

23(36)

16(25)

0.13

   No

13 (17)

9(69)

2(15)

2(15)