Red clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial [ISRCTN42940165]

Table 3 Daily number of hot flushes and menopausal symptom score at baseline and after 12 months, and change from baseline to 12 months by treatment group

	Isoflavone (n = 45, n = 70)^a			Placebo (n = 54, n= 83)^a
	Baseline	12 months	Change	Baseline	12 months	Change	P for change^b
Mean daily number of hot flushes	2.1 ± 2.7	1.2 ± 2.3	-0.8 ± 2.1	2.5 ± 3.0	1.5 ± 2.0	-1.0 ± 1.8	0.41
Menopausal symptom score	4.3 ± 4.3	3.4 ± 4.1	-0.9 ± 4.1	4.3 ± 4.3	3.5 ± 3.8	-0.8 ± 2.8	0.88

Analyses based on women who reported hot flushes or menopausal symptoms in one or both diaries. Values are expressed as means ± standard deviation. ^a Shown in parentueses are the number of women with hot flushes and number of women with any menopausal symptoms, respectively. ^b P value for difference between treatment groups for change.

ISSN: 1465-542X