Table 3 Genotypic and allelic frequencies of estrogen receptor-α in the Taiwanese population: breast cancer group versus control group and breast cancer cases in the presence versus the absence of a family history
ER-α genotypes | ER-α | ||||
|---|---|---|---|---|---|
00 | 01 | 11 | 0 | 1 | |
Exon 1, codon 10 (TCT → TCC)a | |||||
Breast cancer | χ2= 4.949, P = 0.026 | χ2 = 5.566, P = 0.018 | |||
Cases (n = 189 subjects/378 alleles) | 91 (48.1)d | 75 (39.7) | 23 (12.2) | 257 (68.0) | 121 (32.0) |
Controls (n = 177 subjects/354 alleles) | 69 (39.0) | 73 (41.2) | 35 (19.8) | 211 (59.6) | 143 (40.4) |
Family history in case group | χ2= 0.387, P = 0.534 | χ2 = 0.421, P= 0.517 | |||
Presence (n = 17 subjects/34 alleles) | 12 (70.6) | 1 (5.9) | 4 (23.5) | 25 (73.5) | 9 (26.5) |
Absence (n = 163 subjects/326 alleles) | 76 (46.6) | 70 (43.0) | 17 (10.4) | 222 (68.1) | 104 (31.9) |
Exon 4, codon 325 (CCC → CCG)b | |||||
Breast cancer | χ2= 2.910, P = 0.088 | χ2 = 2.723, P= 0.099 | |||
Cases (n = 189 subjects/378 alleles) | 43 (22.7) | 95 (50.3) | 51 (27.0) | 181 (47.9) | 197 (52.1) |
Controls (n = 177 subjects/354 alleles) | 25 (14.1) | 98 (55.4) | 54 (30.5) | 148 (41.8) | 206 (58.2) |
Family history in case group | χ2= 1.020, P = 0.312 | χ2 = 1.055, P= 0.304 | |||
Presence (n = 17 subjects/34 alleles) | 4 (23.5) | 11 (64.7) | 2 (11.8) | 19 (55.9) | 15 (44.1) |
Absence (n = 163 subjects/326 alleles) | 38 (23.3) | 76 (46.6) | 49 (30.1) | 152 (46.6) | 174 (53.4) |
Exon 8, codon 594 (ACG → ACA)c | |||||
Breast cancer | χ2= 0.003, P = 0.957 | χ2 = 0.003, P= 0.956 | |||
Cases (n = 189 subjects/378 alleles) | 128 (67.7) | 52 (27.5) | 9 (4.8) | 308 (81.5) | 70 (18.5) |
Controls (n = 177 subjects/354 alleles) | 117 (66.1) | 55 (31.1) | 5 (2.8) | 289 (81.6) | 65 (18.4) |
Family history in case group | χ2= 3.605, P = 0.058 | χ2 = 3.877, P= 0.049 | |||
Presence (n = 17 subjects/34 alleles) | 15 (88.2) | 2 (11.8) | 0 (0.0) | 32 (94.1) | 2 (5.9) |
Absence (n = 163 subjects/326 alleles) | 107 (65.6) | 48 (29.5) | 8 (4.9) | 262 (80.4) | 64 (19.6) |