Skip to main content

Table 4 Common side-effects reported in two tamoxifen chemoprevention trials

From: Future possibilities in the prevention of breast cancer: Breast cancer prevention trials

Side effect

Trial

Tamoxifen (%)

Placebo (%)

P

Hot flushes

RMH

34

20

<0.001

 

NSABP

78

65

<0.001

Vaginal discharge

RMH

16

4

<0.001

 

NSABP

55

34

<0.001

Menstrual

RMH

14

9

0.002

Irregularities (bleeding)

NSABP

22

21

NS

Nausea

RMH

6

10

0.02

Headaches

RMH

12

14

NS

Mood change

RMH

3

3

NS

 

NSABP

11

12

NS

Weight gain/loss

RMH

7

11

NS

 

NSABP

45

42

NS

  1. NS, not significant. Data for the RMH trial from [13]; Data for the NSABP study from [3*,14].
Back to article page

Breast Cancer Research

ISSN: 1465-542X

Contact us