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Figure 1 | Breast Cancer Research

Figure 1

From: Cell clusters overlying focally disrupted mammary myoepithelial cell layers and adjacent cells within the same duct display different immunohistochemical and genetic features: implications for tumor progression and invasion

Figure 1

Disruptions of myoepithelial cell layers are independent of the size, length, architecture, and overall estrogen receptor (ER) negativity of the ducts. Paraffin-embedded breast tissue sections were double immunostained with antibodies to ER and smooth muscle actin, and were developed with 3,3'-diaminobenzidine (DAB; black or brown) and 3-amino-9-ethylcarbazole (AEC; red) chromogens, respectively. Distinct myoepithelial cell layers are seen in the following structures: (a) a large duct with ductal carcinoma in situ (DCIS), 100×; (b) a long normal duct, 40×; (c) a duct with intraductal hyperplasia, 100×; (d) intermediate grade ER-negative DCIS, 100×.

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