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Table 2 Outcome of patients with 'clinging carcinoma' (flat type, with low nuclear grade/monomorphic nuclei)

From: The diagnosis and management of pre-invasive breast disease: Flat epithelial atypia – classification, pathologic features and clinical significance

 

Eusebi and colleagues [6]

European Organization for Research and Treatment of Cancer Trial 10853 [19]

Number of patients

25

59

Type of study

Retrospective review of breast biopsies originally considered benign

Prospective, randomized clinical trial

Treatment

Diagnostic biopsy; no attempt at excision

Excision alone or excision and radiation therapyb

Follow-up

19.2 years (mean)

5.4 years (median)

Number (%) with local recurrence

1 (4%)a

0

Number with subsequent invasive breast cancer

0

0

  1. aThe 'local recurrence' in this case consisted of a 'clinging carcinoma' lesion histologically identical to the original lesion. It is therefore not possible to determine whether this simply reflects persistence of the original lesion due to inadequate excision or whether this represents a true local recurrence. bNumber of patients in each treatment arm, with pure 'clinging carcinoma' arm not provided.