Table 1 Distribution of breast cancer risk factors among controls in relation to the CYP17 genotype: Western New York Breast Cancer Study
From: CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors
Premenopausal (n = 86) | Postmenopausal (n = 102) | |||
|---|---|---|---|---|
CYP17 genotype | A1/A1 | A1/A2 and A2/A2 | A1/A1 | A1/A2 and A2/A2 |
Age at menarche | ||||
< 13 years | 15 (31) | 18 (49) | 18 (38) | 25 (46) |
≥ 13 years | 33 (69) | 20 (51) | 29 (62) | 30 (54) |
Difficulty getting pregnant | ||||
No | 38 (79) | 29 (76) | 32 (68)* | 47 (86)* |
Yes | 10 (21) | 9 (24) | 11 (23) | 8 (14) |
Age at first birth | ||||
< 25 years | 38 (79) | 28 (74) | 21 (45)* | 40 (73)* |
≥ 25 years | 10 (21) | 10 (26) | 26 (55) | 15 (27) |
Ever use oral contraceptives | ||||
No | 26 (54) | 19 (50) | ||
Yes | 22 (46) | 19 (50) | ||
Family history of breast cancer | ||||
No | 45 (94) | 35 (92) | 43 (91) | 50 (91) |
Yes | 3 (6) | 3 (8) | 4 (9) | 5 (9) |
Age at menopause | ||||
< 48 years | 29 (62) | 29 (53) | ||
≥ 48 years | 18 (38) | 26 (47) | ||
Ever use hormone replacement therapy | ||||
No | 32 (68) | 39 (71) | ||
Yes | 15 (32) | 16 (29) | ||