Figure 2

Canonic Wnt signaling pathway molecules can induce a similar phenotype. When each molecule in the canonic Wnt signaling pathway was activated, they could induce hyperplasias, adenocarcinomas and squamous metaplasias. GSK3, dominant negative glycogen synthase kinase 3β; APC, adenomatous polyposis coli; P, phosphorylated form; dsh, dishevelled.