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Figure 5 | Breast Cancer Research

Figure 5

From: Increased cell survival by inhibition of BRCA1 using an antisense approach in an estrogen responsive ovarian carcinoma cell line

Figure 5

The effect of reduced BRCA1 protein in BG-1 cells on incidence and size of tumor formation in ovariectomized nude mice. (A) BG-1 BRCA1 antisense clone AS-4 (solid bars) and control clone NEO (gray bars) injected at 105 cells per site in matrigel in the presence of an 0.18mg estrogen implanted pellet. (B) BG-1 BRCA1 antisense clone AS-4 (solid bars) and control clone NEO (gray bars) injected at 105 cells per site in matrigel without supplemental estrogen. The upper panels indicate the percentage of injected sites that had tumor development. The lower panels provide the average tumor size in millimeters (length × width) for each clone on indicated days.

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