From: Parity-related molecular signatures and breast cancer subtypes by estrogen receptor status
Study demographics | PVLSI | SHLb[12] | UICHb[24] | PBCS cancer-adjacent normal tissue | PBCS tumor tissue |
---|---|---|---|---|---|
Cancer status | Cancer-free | Cancer-free | Cancer-free | Breast cancer | Breast cancer |
Tissue source | Fresh whole tissue | Core needle biopsies | Microdissected FFPE tissue | Fresh whole tissue | Fresh whole tissue |
Tissue enrichment | Stroma | Epithelial and stromal | Epithelial | Stroma | Epithelial |
Gene expression platform | Agilent 4 × 44K | GeneChip U133Plus 2.0 | RT-PCR of 64 genes | Agilent 4 × 44K | Illumina |
Samples | Â | Â | Â | Â | |
  Total | 130 | 107 | 24 | 150 | |
  ER+, n (%) | N/A | N/A | N/A | 117 (78%) | |
  Parous, n (%) | 76 (58%) | 67 (63%) | 11 (46%) | 119 (79%) | |
  Premenopausal, n (%) | 84 (65%) | 0 (0%) | 24 (100%) | 41 (27%) | |
Mean age (±SD), yr | 37 (13) | 60 (5) | 29 (6) | 56 (10) | |
Mean BMI (±SD) | 30c (6) | 25 (4) | – | 28 (5) |