Loss of histone H4K20 trimethylation predicts poor prognosis in breast cancer and is associated with invasive activity

Table 2 Multivariate analysis of clinicopathological parameters

	Overall survival			Disease-free survival
Variables	HR	(95% Cl)	P*	HR	(95% Cl)	P*
H4K20me3 score (score2 : score 0,1)	2.85	(0.52 to 53.37)	0.263	3.37	(1.09 to 14.80)	0.033
Nuclear grade (G1, G2 : G3)	5.60	(1.19 to 41.07)	0.028	2.52	(0.97 to 6.75)	0.059
ER (positive : negative)	0.93	(0.18 to 3.70)	0.920	1.70	(0.65 to 4.38)	0.272
HER2 (positive : negative)	2.62	(0.67 to 9.30)	0.158	1.43	(0.46 to 3.70)	0.509

*Cox proportional hazards model was used to assess the independent prognostic contribution of H4K20me3 after accounting for other potentially important covariates. HR, hazard ratio; Cl, confidence interval.

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