Chr | Genes in or near region | SNP | Effect allele | RAF in controls | RAF in cases | Per-allele OR (95% CI) | SE | Pvalue* | Pooled OR | FDR-correctedPhet |
---|---|---|---|---|---|---|---|---|---|---|
1 | PEX14 | rs616488 | G | 0.348 | 0.361 | 1.06 (0.89, 1.26) | 0.09 | 0.510 | 0.94 | 0.790 |
1 | PTPN22/BCL2L15/AP4B1/DCLRE1B/HIPK1 | rs11552449 | A | 0.596 | 0.556 | 0.85 (0.72, 0.99) | 0.08 | 0.040 | 1.06 | 0.068 |
1 | FCGR1B | rs11249433 | G | 0.029 | 0.026 | 0.85 (0.52, 1.39) | 0.25 | 0.517 | 1.09 | 0.371 |
2 | INHBB- | rs4849887 | A | 0.259 | 0.269 | 1.05 (0.87, 1.25) | 0.09 | 0.634 | 0.92 | 0.561 |
2 | METAP1D/DLX1/DLX2 | rs2016394 | A | 0.195 | 0.191 | 0.96 (0.79, 1.18) | 0.10 | 0.727 | 0.95 | 0.790 |
2 | TNP1‡ | rs13387042 | G | 0.907 | 0.883 | 0.77 (0.60, 0.99) | 0.13 | 0.045 | 0.93 | 0.062 |
2 | DIRC3 | rs16857609 | C | 0.376 | 0.367 | 1.07 (0.90, 1.27) | 0.09 | 0.462 | 1.08 | 0.977 |
3 | ITPR1/EGOT | rs6762644 | G | 0.098 | 0.096 | 0.97 (0.73, 1.29) | 0.14 | 0.841 | 1.07 | 0.790 |
3 | SLC4A7 | rs4973768 | A | 0.190 | 0.186 | 0.97 (0.80, 1.18) | 0.10 | 0.757 | 1.11 | 0.473 |
3 | TGFBR2 | rs12493607 | G | 0.278 | 0.262 | 0.91 (0.76, 1.09) | 0.09 | 0.290 | 1.06 | 0.619 |
4 | TET2 | rs9790517 | A | 0.613 | 0.635 | 1.09 (0.93, 1.29) | 0.08 | 0.293 | 1.05 | 0.440 |
4 | ADAM29 | rs6828523 | A | 0.275 | 0.271 | 0.99 (0.82, 1.18) | 0.09 | 0.879 | 0.90 | 0.729 |
5 | 5p12 (intergenic) | rs4415084 | C | 0.441 | 0.434 | 0.96 (0.82, 1.14) | 0.08 | 0.668 | 1.15 | 0.087 |
5 | MRPS30 | rs10941679 | G | 0.499 | 0.519 | 1.09 (0.93, 1.29) | 0.08 | 0.289 | 1.12 | 0.409 |
5 | MAP3K1‡ | rs889312 | C | 0.589 | 0.577 | 0.96 (0.82, 1.14) | 0.08 | 0.666 | 1.05 | 0.727 |
5 | RAB3C | rs10472076 | G | 0.247 | 0.260 | 1.07 (0.89, 1.28) | 0.09 | 0.465 | 1.04 | 0.500 |
5 | EBF1 | rs1432679 | G | 0.631 | 0.642 | 1.05 (0.89, 1.24) | 0.08 | 0.558 | 1.07 | 0.931 |
6 | FOXQ1†| rs11242675 | A | 0.597 | 0.633 | 1.15 (0.98, 1.35) | 0.08 | 0.088 | - | - |
6 | ECHDC1/RNF146 | rs2180341 | G | 0.181 | 0.198 | 1.09 (0.90, 1.33) | 0.10 | 0.365 | 1.31 | 0.100 |
6 | RANBP9 | rs204247 | G | 0.588 | 0.611 | 1.10 (0.94, 1.29) | 0.08 | 0.248 | 1.05 | 0.911 |
6 | FAM46A | rs17529111 | G | 0.218 | 0.206 | 0.92 (0.75, 1.12) | 0.10 | 0.404 | 1.06 | 0.675 |
6 | ESR1 | rs3757318 | A | 0.276 | 0.316 | 1.20 (1.01, 1.42) | 0.09 | 0.039 | 1.04 | 0.790 |
6 | ESR1‡ | rs2046210 | A | 0.380 | 0.434 | 1.25 (1.06, 1.46) | 0.08 | 0.008 | 1.27 | 0.970 |
7 | ARHGEF5 | rs720475 | A | 0.046 | 0.041 | 0.90 (0.61, 1.33) | 0.20 | 0.596 | 0.94 | 0.941 |
8 | RPL17P33 | rs9693444 | A | 0.282 | 0.288 | 1.04 (0.87, 1.24) | 0.09 | 0.691 | 1.07 | 0.977 |
8 | 8q24 | rs13281615 | G | 0.502 | 0.500 | 0.99 (0.84, 1.16) | 0.08 | 0.872 | 1.07 | 0.215 |
8 | 8q24 | rs1562430 | C | 0.181 | 0.184 | 1.03 (0.83, 1.27) | 0.11 | 0.820 | 0.87 | 0.273 |
9 | CDKN2A | rs1011970 | A | 0.096 | 0.095 | 0.98 (0.75, 1.28) | 0.14 | 0.875 | 1.07 | 0.639 |
9 | KLF4 | rs10759243 | A | 0.431 | 0.476 | 1.20 (1.02, 1.41) | 0.08 | 0.027 | 1.06 | 0.790 |
9 | KLF4 | rs865686 | C | 0.057 | 0.067 | 1.19 (0.87, 1.64) | 0.16 | 0.275 | 0.90 | 0.150 |
10 | ZNF365 | rs10822013 | T | 0.500 | 0.517 | 1.07 (0.91, 1.25) | 0.08 | 0.409 | 1.08 | 0.387 |
10 | ZNF365‡ | rs10995190 | A | 0.012 | 0.013 | 1.14 (0.57, 2.30) | 0.36 | 0.713 | 1.06 | 0.350 |
10 | ZMIZ1 | rs704010 | A | 0.369 | 0.397 | 1.12 (0.95, 1.33) | 0.08 | 0.169 | 1.08 | 0.473 |
10 | FGFR2‡ | rs1219648 | G | 0.404 | 0.427 | 1.08 (0.92, 1.27) | 0.08 | 0.343 | 1.14 | 0.560 |
10 | FGFR2 | rs2981582 | A | 0.338 | 0.370 | 1.14 (0.96, 1.34) | 0.08 | 0.128 | 1.26 | 0.451 |
11 | LSP1 | rs3817198 | G | 0.095 | 0.108 | 1.14 (0.89, 1.46) | 0.13 | 0.311 | 1.07 | 0.931 |
11 | DKFZp761E198/OVOL1/SNX32/CFL1 | rs3903072 | A | 0.210 | 0.175 | 0.81 (0.66, 0.99) | 0.10 | 0.039 | 0.95 | 0.268 |
11 | BARX2 | rs11820646 | A | 0.489 | 0.509 | 1.09 (0.93, 1.28) | 0.08 | 0.278 | 0.95 | 0.574 |
12 | ATF7IP | rs12422552 | C | 0.273 | 0.325 | 1.29 (1.08, 1.53) | 0.09 | 0.004 | 1.06 | 0.128 |
12 | PTHLH | rs10771399 | G | 0.192 | 0.173 | 0.88 (0.71, 1.08) | 0.11 | 0.221 | 0.86 | 0.729 |
12 | NTN4 | rs17356907 | G | 0.253 | 0.247 | 0.98 (0.82, 1.18) | 0.09 | 0.839 | 0.91 | 0.604 |
14 | PAX9/SLC25A21 | rs2236007 | A | 0.297 | 0.255 | 0.83 (0.69, 0.98) | 0.09 | 0.031 | 0.92 | 0.469 |
14 | CCDC88C | rs941764 | G | 0.126 | 0.140 | 1.13 (0.90, 1.42) | 0.12 | 0.308 | 1.06 | 0.931 |
16 | TOX3 | rs4784227 | T | 0.245 | 0.274 | 1.17 (0.97, 1.41) | 0.09 | 0.098 | 1.23 | 0.574 |
16 | TOX3 | rs3112612 | G | 0.228 | 0.210 | 0.90 (0.74, 1.10) | 0.10 | 0.300 | 1.13 | 0.066 |
16 | CDYL2 | rs13329835 | G | 0.053 | 0.054 | 1.02 (0.70, 1.46) | 0.18 | 0.938 | 1.09 | 0.351 |
16 | MIR1972-2/FTO | rs17817449 | C | 0.140 | 0.118 | 0.83 (0.66, 1.06) | 0.12 | 0.134 | 0.93 | 0.079 |
18 | AQP4‡ | rs527616 | G | 0.267 | 0.266 | 0.99 (0.83, 1.19) | 0.09 | 0.951 | 0.98 | 0.805 |
18 | CHST9 | rs1436904 | C | 0.486 | 0.509 | 1.09 (0.93, 1.28) | 0.08 | 0.287 | 0.96 | 0.225 |
19 | C19orf61:KCNN4:LYPD5:ZNF283 | rs3760982 | A | 0.136 | 0.148 | 1.10 (0.87, 1.38) | 0.12 | 0.437 | 1.06 | 0.994 |
21 | NRIP1 | rs2823093 | A | 0.035 | 0.032 | 0.90 (0.57, 1.40) | 0.23 | 0.631 | 0.92 | 0.994 |