Table 1 List of mouse models in the dataset

Myc

319

MMTV WAP/Dox

Myc mammary tumors of various histological types, expression levelsand stability with variable Kras mutations.

[15, 19, 20, 35–38]

Neu

124

MMTV

Induction of adenocarcinomas with pulmonary metastasis.

[11, 15, 38–44]

PyMT

119

MMTV K6/RCAS MMTV/RCAS

Rapid induction of luminal-type mammary tumors with pulmonarymetastasis.

[38, 45–48]

SV40 Large T Antigen

107

C3 WAP

Induction of mammary tumors with similarities to human basal typebreast cancer.

[11, 38, 49–51]

p53

92

Null

Tumors with similarities to human basal type breast cancer.

[11, 38, 52, 53]

CreEtv6/NTRK3

63

WAP

Fusion oncoprotein transforms through activation of AP1.

[54]

MET

52

MMTV

Diverse histologies with similarities to human basal breastcancer.

[16]

BRCA/p53

46

WAP MMTV BLG

CKO of BRCA1 in a p53 null background. Tumors similar to human basalbreast cancer.

[38, 55]

Wnt

35

MMTV

Induction of mammary tumors with diverse gene expression patterns.

[38, 56–58]

IGF-IR

26

MTB

Basal-like mammary tumors. Recurrent tumors resemble humanclaudin-low.

[59]

LPA

16

MMTV

ER positive, metastatic tumors.

[60]

Stat5

16

BLG

Induction of mammary tumors

NA

Brg1 (+/−)

14

Mutant

Heterogeneous breast cancers.

[61]

DMBA

12

Chemical

Mammary carcinomas with three phenotypes: adenocarcinoma, squamouscell carcinoma, and myoepithelial cell carcinoma.

[62]

Ras

10

MMTV

Induction of mammary tumors with rapid tumor onset.

[38]

Int3

9

WAP

Metastatic tumors.

[63]

RB/p107

7

CKO

Adeno and adenosquamous carcinomas similar to luminal B or basal.

[64]

APC CKO

6

K14-Cre

CKO results in adenocarcinomas with histological and molecularheterogeneity.

[65]

Autotaxin (ATX)

5

MMTV

ER + metastatic mammary tumors.

[60]

BRCA

5

CKO

Tumors similar to human basal type breast cancer.

NA

STAT1

5

Knockout

ERa + PR+, hormone dependent like humanERa + luminal.

[66]

Notch

4

Dox

Induction of mammary adenocarcinomas.

NA

PDK1

2

MMTV

Induction of mammary tumors

[67]

Normal Mammary Gland

47

Not Applicable

Normal mammary gland samples from FVB, BalbC, and CD1 geneticbackgrounds.

[16, 44, 60]