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Figure 6 | Breast Cancer Research

Figure 6

From: JMJD2A contributes to breast cancer progression through transcriptional repression of the tumor suppressor ARHI

Figure 6

E2F and histone deacetylase (HDAC) are involved in the transcriptional inhibition of ARHI by JMJD2A. (A) Specific siRNAs against E2F1 and E2F4 were efficient to knockdown E2F1 and E2F4 expression level. (B) Effects of E2Fs knockdown on JMJD2A binding to the A2 site of the ARHI promoter. Both siRNAs could inhibit the binding of JMJD2A to the ARHI promoter. (C) Effects of JMJD2A-FL, JMJD2A mutants (H188A and M867) and trichostatin A (TSA) on ARHI promoter activity. *P <0.05, **P <0.01. ARHI, Aplasia Ras homolog member I.

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