Trial of CDK4/6 agent | Target disease | Trial phase |
---|---|---|
PD-0332991/Palbociclib (Pfizer; New York, NY, USA) | Â | Â |
A Study of Palbociclib in Addition to Standard Endocrine Treatment in Hormone Receptor Positive Her2 Normal Patients with Residual Disease after Neoadjuvant Chemotherapy and Surgery (PENELOPE-B) (ClinicalTrials.gov NCT01864746) | ER-positive (adjuvant) | III |
PD 0332991 and Anastrozole for Stage 2 or 3 Estrogen Receptor Positive and HER2 Negative Breast Cancer (ClinicalTrials.gov NCT01723774) | ER-positive (neoadjuvant) | II |
A Study of PD-0332991 + Letrozole vs. Letrozole for 1st Line Treatment of Postmenopausal Women with ER+/HER2- Advanced Breast Cancer (ClinicalTrials.gov NCT017240427) | ER-positive (first-line advanced) | III |
PD0332991/Paclitaxel in Advanced Breast Cancer (ClinicalTrials.gov NCT01320592) | All metastatic | Ib |
LEE011 (Novartis; New York, NY, USA) | Â | Â |
Phase Ib/II Trial of LEE011 with Everolimus (RAD001) and Exemestane in the Treatment of ER+Her2- Advanced Breast Cancer | ER-positive (advanced/metastatic) | Ib/II |
Study of LEE011, BYL719 and Letrozole in Advanced ER+ Breast Cancer (ClinicalTrials.gov NCT01872260) | ER-positive (advanced/metastatic) | Ib/II |
A Pharmacodynamics Pre-surgical Study of LEE011 in Early Breast Cancer Patients (MONALEESA-1) (ClinicalTrials.gov NCT01919229) | ER-positive (neoadjuvant) | II |
Study of Efficacy and Safety of LEE011 in Postmenopausal Women with Advanced Breast Cancer (MONALEESA-2) (ClinicalTrials.gov NCT01958021) | ER-positive (advanced/metastatic) | II |