From: Role of the androgen receptor in breast cancer and preclinical analysis of enzalutamide
 | Tamoxifen failure 5 years | DFS overall | DSS overall | ||||
---|---|---|---|---|---|---|---|
Variable | n | HR (95% CI) | Pvalue | HR (95% CI) | P value | HR (95% CI) | P value |
Age <50 | 16 | 1.00 | Â | 1.00 | Â | 1.00 | Â |
Age ≥50 | 175 | 0.49 (0.22, 1.08) | 0.08 | 0.69 (0.33, 1.46) | 0.33 | 0.79 (0.33, 1.87) | 0.58 |
Tumor size ≤2 cm | 105 | 1.00 |  | 1.00 |  | 1.00 |  |
Tumor size >2Â cm | 86 | 1.92 (1.08, 3.42) | 0.03 | 1.95 (1.18, 3.24) | 0.01 | 2.39 (1.32, 4.31) | 0.004 |
Tumor grade 1 | 15 | 1.00 | Â | 1.00 | Â | 1.00 | Â |
Tumor grade 2 | 112 | 1.78 (0.42, 7.54) | 0.43 | 1.33 (0.47, 3.74) | 0.59 | 1.05 (0.37, 3.02) | 0.92 |
Tumor grade 3 | 63 | 3.33 (0.78, 14.2) | 0.10 | 2.05 (0.71, 5.90) | 0.18 | 1.52 (0.51, 4.51) | 0.45 |
LN-negative | 63 | 1.00 | Â | 1.00 | Â | 1.00 | Â |
LN-positive | 83 | 3.41 (1.40, 8.31) | 0.01 | 2.42 (1.19, 4.94) | 0.02 | 2.12 (0.95, 4.75) | 0.07 |
%ER, continuous | 192 | 0.98 (0.98, 0.99) | 0.0002 | 0.99 (0.98, 0.99) | 0.0004 | 0.99 (0.98, 0.99) | 0.001 |
AR = 0% | 20 | 1.00 |  | 1.00 |  | 1.00 |  |
AR >0% | 171 | 0.61 (0.27, 1.36) | 0.23 | 0.91 (0.42, 2.01) | 0.82 | 1.20 (0.43, 3.33) | 0.73 |
AR/ER < 2 | 169 | 1.00 |  | 1.00 |  | 1.00 |  |
AR/ER ≥ 2 | 22 | 4.43 (2.33, 8.42) | <0.0001 | 4.40 (2.47, 7.83) | <0.0001 | 3.66 (1.94, 6.93) | <0.0001 |
PR-negative | 22 | 1.00 | Â | 1.00 | Â | 1.00 | Â |
PR-positive | 108 | 0.43 (0.18, 1.04) | 0.06 | 0.62 (0.27, 1.43) | 0.26 | 0.69 (0.26, 1.84) | 0.46 |
MIB-1 <21.3 | 93 | 1.00 | Â | 1.00 | Â | 1.00 | Â |
MIB-1 ≥21.3 | 95 | 1.17 (0.66, 2.07) | 0.59 | 0.98 (0.59, 1.61) | 0.93 | 0.98 (0.55, 1.73) | 0.94 |
Mitotic index number ≤4 | 94 | 1.00 |  | 1.00 |  | 1.00 |  |
Mitotic index number >4 | 92 | 1.64 (0.92, 2.94) | 0.10 | 1.54 (0.93, 2.55) | 0.10 | 1.34 (0.77, 2.37) | 0.30 |
erbB2 ≤30% | 152 | 1.00 |  | 1.00 |  | 1.00 |  |
erbB2 >30% | 16 | 1.02 (0.36, 2.84) | 0.98 | 0.71 (0.26, 1.96) | 0.51 | 0.69 (0.22, 2.24) | 0.54 |
EGFR = 0% | 139 | 1.00 |  | 1.00 |  | 1.00 |  |
EGFR >0% | 26 | 1.31 (0.60, 2.83) | 0.50 | 1.01 (0.50, 2.07) | 0.97 | 1.17 (0.54, 2.51) | 0.70 |