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  • Poster presentation
  • Open Access

PB.46: Peutz-Jeghers Syndrome and carcinoma of the breast: call for new breast imaging surveillance guidelines

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Breast Cancer Research201315 (Suppl 1) :P46

  • Published:


  • Breast Cancer
  • Pancreatic Cancer
  • Develop Breast Cancer
  • Tertiary Referral Centre
  • Breast Imaging


Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominantly inherited polyposis syndrome caused by STK11 germline mutation. PJS is characterised by gastrointestinal polyps and mucocutaneous pigmentation. These patients have an increased risk of developing cancers, luminal gastrointestinal cancers and breast cancer being the most common, then pancreatic cancer [1, 2].


A retrospective review of a prospectively maintained database at a tertiary referral centre was carried out. A total of 136 patients from 92 families were included.


The median age when patients were first seen was 20 years (range, 2 to 65). Twenty-seven carcinomas were detected in 19 patients; 15 were carcinoma of the breast (55%) (two patients had bilateral disease). All of the breast cancers were in women and were predominantly ductal carcinoma in situ. Of the 13 patients with breast cancer, a STK11 mutation was detected in eight (62%).


The cumulative risk of developing breast cancer is 31 to 54% at age 60 years, with a median age at diagnosis of 37 years (range, 19 to 48 years) in PJS patients [3]. Published European guidelines recommend annual magnetic resonance imaging of the breast from age 25 to 30 years, with mammography being substituted after age 50 years [3], which we endorse.

Authors’ Affiliations

Northwick Park and St Mark's Hospitals, Northwest London Hospitals NHS Trust, London, UK


  1. Giardiello FM, Brensinger JD, Tersmette AC, et al: Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology. 2000, 119: 1447-1453. 10.1053/gast.2000.20228.View ArticlePubMedGoogle Scholar
  2. Hearle N, Schumacher V, Menko FH, et al: Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res. 2006, 12: 3209-3215. 10.1158/1078-0432.CCR-06-0083.View ArticlePubMedGoogle Scholar
  3. Beggs AD, Latchford AR, Vasen HF, et al: Peutz-Jeghers syndrome: a systemic review and recommendations for management. Gut. 2010, 59: 975-986. 10.1136/gut.2009.198499.View ArticlePubMedGoogle Scholar


© Tsang et al.; licensee BioMed Central Ltd. 2013

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.