- Poster presentation
- Open Access
PB.33: Vacuum-assisted biopsy for lesions of uncertain malignant potential: further evidence of its suitability as a safe alternative to surgery
Breast Cancer Research volume 15, Article number: P33 (2013)
Increasing evidence supports vacuum-assisted biopsy (VAB) instead of surgical excision for the management of lesions of uncertain malignant potential (B3). This followed reports of up to 34% upgrade to malignancy on excision. In January 2012, regional guidance was adopted to clarify the options for managing such lesions. In our department, we have used similar local guidelines since 2011. We report our analysis of the management of B3 lesions before and after the introduction of VAB.
All B3 lesions were identified retrospectively, using our screening database, before (1 January 2008 to 31 December 2009) and after (1 January 2011 to 31 December 2012) VAB use. Final pathological diagnosis following surgical excision or VAB was recorded for both groups. The findings of annual surveillance mammography were also recorded for lesions which remained B3 but were radiologically excised following VAB.
Before the use of VAB there were 94 B3 lesions, 80 (85%) of which underwent surgical excision. After the use of VAB there were 85 B3 lesions, of which 17 (20%) went on to have diagnostic surgery. The percentage of upgrade to malignancy following further sampling was equal in both groups, at 18%. Sixteen of 26 lesions, which remained B3 following VAB excision, had surveillance mammography, none of which demonstrated suspicious findings.
Our study provides further evidence that VAB is a safe alternative to surgery for the management of B3 lesions, with identical upgrade rates and reassuring follow-up results, following its use in our department.
Rajan S, Shaaban AM, Dall BJ, Sharma N: New patient pathway using vacuum-assisted biopsy reduces diagnostic surgery for B3 lesions. Clin Radiol. 2012, 67 (3): 244-9. 10.1016/j.crad.2011.09.002.
Tennant SL, Evans A, Hamilton LJ, James J, Lee AH, Hodi Z, Ellis IO, Rakha EA, Wilson AR: Vacuum-assisted excision of breast lesions of uncertain malignant potential (B3) - an alternative to surgery in selected cases. Breast. 2008, 17 (6): 546-9. 10.1016/j.breast.2008.08.005.
Lieske B, Ravichandran D, Alvi A, Lawrence DA, Wright DJ: Screen-detected breast lesions with an indeterminate (B3) core needle biopsy should be excised. Eur J Surg Oncol. 2008, 34 (12): 1293-8. 10.1016/j.ejso.2007.11.005.
Wilkinson LS, Wells C, Teh W, Desai A, Wilson R: The management of indeterminate breast lesions - a clinicians guide. London region quality assurance reference centre. Guidance on management of indeterminate breast lesions. 2012
About this article
Cite this article
Tzias, D., Bhaludin, B., Wilkinson, L. et al. PB.33: Vacuum-assisted biopsy for lesions of uncertain malignant potential: further evidence of its suitability as a safe alternative to surgery. Breast Cancer Res 15, P33 (2013) doi:10.1186/bcr3533
- Cancer Research
- Pathological Diagnosis
- Malignant Potential
- Safe Alternative
- Local Guideline