Table 2 Functional characterization of isolated epithelial cell subpopulations

Myoepithelial^a

32.7 ± 7.4%^a

9.6 ± 2.3%^a

0%

0%

Basal stem/progenitor^a

66.2 ± 7.2%^a

9.3 ± 4.5%^a

26.1 ± 2.7%

0%

Luminal Sca1^-b

36.3 ± 5.6%^b

31.3 ± 2.6%^b

84.0 ± 3.4%

57.1 ± 2.9%

Luminal Sca1^+a

73.3 ± 1.8%^a

71.8 ± 4.1%^a

64.1 ± 3.6%

59.8 ± 2.7%

B

Number of basal stem/progenitor cells injected per cleared fat pad

Number of positive outgrowths ^{c, d, e}

Age-matched virgin control donors

Parous donors

1,000

^c8/9

^d8/9

^e8/9

^c3/9

^d3/9

^e4/9

500

^c8/11

^d8/11

^e8/11

^c2/11

^d2/11

^e6/11

250

^c2/6

^d2/6

^e2/6

^c0/6

^d1/6

^e1/6

100

^c0/6

^d1/6

^e1/6

^c0/6

^d0/6

^e2/6

50

^c0/7

^d0/7

^e0/7

^c1/7

^d1/7

^e1/7

Repopulating frequency (95% confidence interval)

^c1/507 (1/827 - 1/311)

^c1/2468 (1/5,522 to 1/1104)

^d1/472 (1/767 - 1/291)

^d1/2095 (1/4,441 to 1/988)

^e1/472 (1/767 - 1/291)

^e1/907 (1/1582 - 1/520)

P value

^cP = 0.0004; ^dP = 0.0004; ^eP = 0.076.