Figure 9
From: Arthritis augments breast cancer metastasis: role of mast cells and SCF/c-Kit signaling
Decreased differentiation of mast cells (MCs) from bone marrow (BM) precursors in mice treated with anti-SCF or anti- c-Kit antibody. (A) Significant reduction in the differentiation of BMMCs in mice treated with neutralizing stem-cell factor (SCF) or cKit antibodies (*P < 0.05; **P < 0.01). (B through D) Representative images of BMMCs showing diminution of MC population in treated group (A through D, 10 mice). (E) Significant reduction in migration of 4T1 cells toward MCs from mice treated with anti-SCF or anti-cKit (**P < 0.01; ***P < 0.001).