Figure 11

Significant reduction in number of mast cells (MCs) (toluidine staining) in the tumors, lungs, and bones of mice treated with anti-stem cell factor (SCF) or anti- c-Kit antibody. (A through C) Significant reduction in number of MCs in (A) tumors (**P < 0.01), (B) lungs (*P < 0.05; ***P < 0.01), and (C) bones (**P < 0.01; ***P < 0.001) of treated mice. (D through F) Representative images of MCs toluidine in (D) tumors, (E) lungs, and (F) bones (200× magnification) (six mice per experimental group and 10 fields per section per organ). Purple-blue staining represents MCs toluidine expression.