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Figure 5 | Breast Cancer Research

Figure 5

From: HIF-1α stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma

Figure 5

Model of the PGE 2 -mediated regulation of aromatase expression by HIF-1α in breast ASCs. Tumor-derived factor PGE2 increases HIF-1α transcript expression and nuclear localization. HIF-1α dimerizes with HIF-1β and then translocates to nucleus where it interacts with the proximal CRE of aromatase PII. HIF-1α together with CREB, CRTCs, CBP and p300 act to increase the PII-driven expression of aromatase.

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