Sensitivity in breast cancer | Specificity in healthy and benign breast disease controls | Pvalueb | AUC (95% CI) | PPV | NPV | |||
---|---|---|---|---|---|---|---|---|
Genea | Methylation positive | % | Methylation negative | % | % | % | ||
RASSF1A ITIH5 | 75 of 138 | 54 | 127 of 174 | 73 | 7.8 × e-6 | 0.647 (0.585-0.709) | 61 | 67 |
RASSF1A DKK3 | 82 of 138 | 59 | 131 of 174 | 75 | 1.6 × e-8 | 0.686 (0.626-0.747) | 66 | 70 |
DKK3 ITIH5 | 55 of 138 | 40 | 164 of 174 | 94 | 1.6 × e-7 | 0.673 (0.611-0.735) | 85 | 66 |
RASSF1A DKK3 ITIH5 | 92 of 138 | 67 | 125 of 174 | 72 | 1.3 × e -10 | 0.712 (0.653-0.770) | 65 | 73 |